Random forest modelling showed that APOE ε4 brain proteins reliably classified APOE ε4 carriers versus non-carriers with AD (dlPFC AUC = 0.94; STG AUC = 0.91), independent of sex and race for dlPFC (AUC > 0.88; Extended Data Table 3; Fig. 2a). The gene discussed is APOE; the disease is Alzheimer disease.