We then analyzed 6,340 CSF proteins from n = 526 AD and n = 573 non-impaired controls (Supplementary Table 1), identifying 51 APOE ε4-associated proteins (mutual information > 0.1) that similarly clustered by carrier status and allele dose (Supplementary Table 3; Extended Data Fig. 1d-f). This evidence concerns the gene APOE and Alzheimer disease.