The heart age gap was most strongly associated with coronary heart disease (HR: 1.21(95% CI: 1.12–1.30), after the conventional, organismal and lung clocks (Figure 6F), while the artery clock was most strongly associated organ specific clock with stroke (HR: 1.24 (95% CI: 1.11–1.37, Figure 6G). Here, CLOCK is linked to coronary artery disorder.