Our results indicate that stimulation with TNF-α or thrombin augments fibrinolytic factors, including PAI-1, tPA, and uPA gene expression/protein secretion in HCAECs, a phenomenon linked to the cytokine storm in various pathological states, including stroke, trauma, and COVID-19 [25,[53], [54], [55], [56]]. This evidence concerns the gene SERPINE1 and stroke disorder.