Forty-seven patients (24%) were already diagnosed with a bleeding disorder at their first consultation, including VWD (n = 27), immune-mediated thrombocytopenia (n = 5), platelet aggregation defect (n = 4), symptomatic carriership of hemophilia A (n = 3), and mild hemophilia A (n = 2; Figure 2A). This evidence concerns the gene VWF and hemorrhagic disease.