CLDN1 and hypertensive disorder: High-salt diet is an important factor for hypertension, which can deplete Lactobacillus in mice (108), while candesartan can counteract the decrease of Lactobacillus caused by hypertension, and candesartan treatment also increases the intestinal expression of genes encoding tight junction proteins (such as zonula occludens, occludin, and claudin-1), improving increased intestinal permeability caused by hypertension and preventing gut microbiota translocation (105).