In ACC, a positive correlation was observed between PDCL3 expression and T helper 2 (Th2) cell infiltration; In contrast, PDCL3 expression was negatively correlated with several immune cell types, including Mast cells, Cytotoxic cells, NK CD56bright cells, Th1 cells, Central memory T cells (Tcm), TFH, B cells, T cells, Neutrophils, NK CD56dim cells, CD8 T cells, plasmacytoid dendritic cells (pDCs), and Macrophages (Figure 6A). The gene discussed is PDCL3; the disease is adrenal cortex carcinoma.