LCN2 and acute kidney injury: Some studies have shown significant correlations among urinary mtDNA level and serum creatinine, eGFR, and the AKI marker neutrophil gelatinase-associated lipocalin (NGAL), suggesting the promising potential of urinary mtDNA as a biomarker for predicting AKI severity, which needs to be further validated by larger, multicenter-like cohort studies in the future to establish the role of urinary mtDNA in predicting AKI severity (128–130).