IL4 and neoplasm: Tumor cells mediate membrane cholesterol efflux in TAMs via secreting hyaluronic acid, causing lipid raft depletion and promoting STAT6 and PI3K-mTORC2-Akt signaling pathways activation, which enhanced IL-4 signaling and inhibited gene expression induced by IFN-γ, eventually induced TAMs toward the M2 phenotype.