NOX4 and neoplasm: Mutations or inactivation of components in this pathway upregulate Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding motif (TAZ), enhancing the expression of ACSL4, TfR1, NADPH oxidase 4 (NOX4), and other factors, thus increasing the sensitivity of tumor cells to ferroptosis (Figure 2) (74).