The cross-species applicability of Trim47 function is particularly intriguing: while its mammalian ortholog functions as a cancer biomarker, the SPRY domain of Trim47 in sensing and degrading viral proteins and immunoprotection capability of gcTrim47-PYD1 in resisting GCRV-II infection demonstrate its possible application as immunoenhancing agents. The gene discussed is TRIM47; the disease is cancer.