Teleost fish exhibit analogous yet species-specific mechanisms: zebrafish FTR36 activates the RIG-I/IRF3/IRF7 axis to combat SVCV and giant salamander iridovirus (GSIV) infection through coordinated functions of its RING and B30.2 domains (36), while Trim2b targets SVCV nucleoprotein (N) and glycoprotein (G) via its NHL_TRIM2_like domain for proteolytic degradation (17). This evidence concerns the gene IRF3 and infection.