Subsequently, based on the PPI network, we identified the Top 10 key genes from the 187 overlapping genes (Figure 2c), including AR, JUN, NEFL, MYH7, KCNIP3, GRIK2, CASK, TNNT1, NEB, and DMD. These genes may play an important role in the aggressive progression of PAs. This evidence concerns the gene GRIK2 and gonorrhea.