EPO and obesity due to melanocortin 4 receptor deficiency: Other systemic factors include osteoporosis, rheumatoid arthritis (RA), Sjögren’s syndrome, sarcoidosis, hypocalcemia, osteomalacia, Paget’s disease of bone, vitamin D deficiency, erythropoietin therapy, cyclophosphamide therapy, obesity, and alcohol intake, which also elevate the risk of MRONJ [6].