RBL2 and neoplasm: Additionally, various in vitro and in vivo studies have shown that Rb2 can inhibit tumor growth and metastasis (Sato et al., 1994; Dai et al., 2019), protect against UV-induced skin photoaging (Oh et al., 2015), and possibly assist in treating viral infections (Yoo et al., 2013; Nguyen and Nguyen, 2019).