Puerarin has a significant inhibitory effect on a hypoxia-induced myocardial ischemia model in mammary rat cardiomyocytes, as evidenced by the reduction of LC-3II/LC-3I and the elevation of p62 and protein kinase B (pAkt)/Akt expression (Tang et al., 2017). The gene discussed is AKT1; the disease is myocardial ischemia.