An extract of PL can ameliorate postmenopausal osteoporosis by decreasing the levels of bone markers C-telopeptide of crosslinked collagen type I (CTX-1), osteocalcin (OC), and dye-decolorizing peroxidase (DYP) and upregulating ER-α protein expression in ovariectomized rats (Lee et al., 2021). This evidence concerns the gene BGLAP and postmenopausal osteoporosis.