IDH2 and neoplasm: With respect to sex, it is known that males have a higher prevalence of glioma than females.23 Sex-specific germline risk associations have been reported for adult diffuse glioma6,7 and interactions between IDH tumor mutation and sex have been observed, particularly with respect to cellular composition.24 However, we did not observe statistically significant differences across males and females with respect to associations of germline variants and IDH tumor mutation status.