D2HGDH and central nervous system cancer: A different variant in the PHLDB1 region (rs498872) has been shown to be associated with risk of glioma in East Asians; however, the two variants are correlated.14 These findings demonstrate the need to evaluate the function and identify the causal variants for the D2HGDH and PHLDB1 regions as these variants may explain why patients that do not have the rs55705857 causal variant develop IDHmut adult brain tumors.