D2HGDH and central nervous system cancer: The D2HGDH variant, rs71430382, was originally identified to be associated with risk of developing an IDHmut glioma via a case–control GWAS.10 Variants in TERT and MAML2 were nominally significant in the meta-analysis; both regions were previously shown to be associated with risk of IDHwt and IDHmut glioma, respectively (Supplementary Table S1).