For this purpose, UC samples were reanalyzed according to the tumor origin; both renal pelvis cancer and ureter cancer showed significantly higher methylation levels of PCDHGB7 with a sensitivity of 87.8% (95% CI: 73.8%–95.9%) and 81.5% (95% CI: 68.6%–90.8%), respectively (Figure 5b–d and Table S6), demonstrating that PCDHGB7 evaluation could provide an efficient detection method for UTUC management in a noninvasive way. Here, PCDHGB7 is linked to malignant renal pelvis neoplasm.