After in vivo injection (Figure 17b), the biomimetic TEPG showed: (1) specific tumor‐homing and enhanced accumulation at ESCC tumors, due to the homotypic tumor‐targeting features of the ESCC membrane; (2) tumor hypoxia relief via the catalase‐mediated H2O2‐to‐O2 decomposition; (3) superior NIR‐induced PDT effects via chlorophyll photosensitivity, and (4) effective GSH depletion by gambogic acid. This evidence concerns the gene CAT and esophageal squamous cell carcinoma.