While neutrophil membranes could inhibit neutrophils chemotaxis and intratumoral infiltration, and suppress M1‐to‐M2 macrophage polarization to reprogram the immunosuppressive tumor microenvironment, enzymes on the red blood cell membrane (e.g., catalase) could decompose intratumoral H2O2 (produced by palmitoyl ascorbate) to generate O2, thereby reducing tumoral hypoxia and enhancing Ce6‐mediated SDT efficacy. This evidence concerns the gene CAT and neoplasm.