In this study, HepG2 cancer cell membranes surface‐functionalized with transferrin (a tumor‐targeting ligand) were capable of improving the efficacy and safety of PDT interventions via enhancing photosensitisers' accumulation in homologous HCC tumor sites, when they were applied to cover hypocrellin B bionic PEG‐PLGA NPs. The gene discussed is TF; the disease is neoplasm.