In an effort to develop a combinational PTT‐immunotherapy approach against primary and metastatic colorectal cancer, hollow gold nanocage nanocomposites loaded with galunisertib (a transforming growth factor‐β [TGF‐β] inhibitor) were coated with a macrophage membrane functionalized with the monoclonal antibody against programmed cell death ligand 1 (anti‐PDL1 antibody, an immune checkpoint inhibitor).99 The gene discussed is CD274; the disease is metastatic colorectal cancer.