(1) The prokineticin 2 level was higher in AIS patients compared with the healthy subjects, and it could sperate the AIS patients from the HCs with the best cut-off value at 4 ng/mL; (2) Prokineticin 2 was positively associated with the inflammatory indexes such as the HsCRP, TNF-α, and IL-17A; (3) The value of prokineticin 2 in estimating the functional recovery was limited in AIS patients. The gene discussed is TNF; the disease is androgen insensitivity syndrome.