STAT3 and cancer: Overexpression of FXR was highly correlated with bladder cancer progression, reducing the expression of integrin β1, integrin β3, p-FAK and p-MLC on the one hand, leading to the downregulation of the migration and adhesion ability of bladder cancer cells, and decreasing VEGF in the endothelial cells to inhibit angiogenic ability on the other hand, as well as enhancing the proteasomal degradation, leading to the downregulation of VEGFA, p-STAT3 and HIF1α and reduced angiogenesis to reach cancer inhibition (50).