After variables with P < 0.05 in the univariable analysis were included in the multivariate analysis, the CA125 level (OR, 1.09 [95% CI: 1.04, 1.14]; P < 0.001), tumor size (OR, 1.06 [95% CI: 1.03, 1.10]; P < 0.001), and APTw_h3 values (OR, 9.40 [95% CI: 7.98, 12.26]; P < 0.001) were retained as independent predictors of LVSI positivity (Table 4). The gene discussed is MUC16; the disease is neoplasm.