For example, integrating radiomic features with spatial transcriptomic atlases of the tumor microenvironment (TME): spatial transcriptomic sequencing (10x Visium) generates gene expression matrices of tumor regions, and graph attention networks (GATs) establish quantitative models linking CT imaging texture features (e.g., gray-level co-occurrence matrix entropy) to EGFR signaling pathway activation (e.g., PI3K-Akt-mTOR). The gene discussed is AKT1; the disease is neoplasm.