IBSP and cancer: The trend topic analysis of the keywords (Table 7; Figure 7c) showed that from 2004 to 2009, the research in this period mainly focused on fdg pet, messenger-rna, bone sialoprotein, polymerase-chain-reaction, liver-tumors, hormone-related protein, prognostic factors, etc. Since 2010, there had been an explosion of research interest in this direction, mainly involving survival, cancer, therapy, management, expression, metastases, bone-marrow, chemotherapy, etc; In addition, from 2022 to 2024, keywords such as “immunity,” “gastrectomy,” and “guidelines” had frequently appeared.