Amyloid aggregation is considered to be one of leading causes behind cognitive impairment and onset of several debilitating neurodegenerative diseases (Wells et al., 2021; Wolfe and Cyr, 2011) collectively referred to as amyloidosis (Metkar et al., 2024) Tau proteins representing the characteristic pathology of Alzheimer’s disease (Chen and Yu, 2023) are normally associated with stabilization of neuronal microtubules (Jesu et al., 2004), but give rise to fibrillar tangles along with β-amyloid under a hyperphosphorylated state. The gene discussed is MAPT; the disease is Alzheimer disease.