RAB5A and Huntington disease: In HD tissue, key upregulated genes included dicarboxylate carrier SLC25A8 (Ucp2), a mitochondrial uncoupling protein that may modulate reactive oxygen species (ROS) production [78] and Ras-related protein Rab-5A (Rab5a), which is essential for endocytic vesicle trafficking and symbiont uptake [79,80] (figure 5 and electronic supplementary material, table S15).