The circulating PSP/reg level in the septic shock group (median, 611.1 ng/ml [IQR, 477.8–795.2 ng/ml]) was significantly higher than that in the sepsis group (median, 209.9 ng/ml [IQR, 165.2–307.7 ng/ml]) (P < 0.01) and the severe sepsis group (median, 409.3 ng/ml [IQR, 327.3–557.1 ng/ml]) (P < 0.05) (Figure 1B). The gene discussed is REG1A; the disease is Sepsis.