Through targeted gene expression profiling (PanCancer iO360, Nanostring) of key CLL microenvironment niches, we discovered that OPN5 treatment of AT Eμ-TCL1 mice reduced the expression of genes related to MDSC function (e.g., Cd36, Cd38, Cd84, Entpd, and Adora2) [24]. Here, CD84 is linked to B-cell chronic lymphocytic leukemia.