Consistent with the observations in vitro, the mRNA levels of c-Jun target genes, Cxcl1, Dusp1, Fgb, and Ppp1r15a, regulated by ALDOA were significantly decreased in the cancer tissues of AAV8-shAldoa mice compared with AAV8-GFP mice (Fig. 8L). Here, CXCL1 is linked to cancer.