Consistently, the tumor volume of the HCCLM3-sgALDOA group was markedly smaller than the sgCtrl group (Fig. S2A), while xenograft tumors of ALDOA knockout group displayed similar intrahepatic dissemination and pulmonary metastases to the sgCtrl group on week 6 after transplantation (Figs. S2B–D). This evidence concerns the gene ALDOA and neoplasm.