Kinases, existing universally in various species, have predominantly been thought as oncogenes involving tumorigenesis for many decades [7, 8], in spite of the opposite evidence that shows several kinases [e.g., protein kinase C (PKC), mitogen-activated protein kinase kinase 4 (MAPKK4/MEK4), and death-associated protein kinase 3 (DAPK3)] function as tumor suppressors [7]. Here, MAP2K4 is linked to neoplasm.