FN1 and infection: Thanks to the presence of specific domains, it may bind to various biological macromolecules, such as collagen, integrin, and other ECM components.[23, 24, 25] Furthermore, several pathogenic bacteria exploit FN as a receptor and binding spot to firmly adhere to host cells, a crucial step in their invasion and immune evasion.[26] These FN‐mediated mechanisms constitute a major virulence factor for many Gram‐negative bacteria, enabling them to establish persistent and resistant infections.[20, 22, 27, 28]