GDF15 and hyperemesis gravidarum: In parallel, studies showed GDF15's increases up to d = 0.27 in hyperemesis gravidarum (Fejzo et al. 2019) and d = 1.4 for patients with cancer anorexia (Molfino et al. 2020) Current results estimate GDF15's increases in AN to be at the upper limit of these comparisons (d = 1.83), indicating strong robust elevations in this clinical condition.