Table 2 shows the GWS loci, including a SNP in an intergenic region near ephrin receptor A5 (EPHA5; rs141838133, OR = 1.66, p = 1.66 × 10–8) in individuals with onset < 75 years, in glutamate ionotropic receptor NMDA type subunit 3B (GRIN3B) near the known AD risk gene ABCA7 (rs115882880, OR = 0.74, p = 1.8 × 10–9) in females, and between the genes thrombospondin type laminin G domain and EAR repeats (TSPEAR);and ubiquitin-conjugating enzyme e2 g2 (UBE2G2) in APOE-ε4 non-carriers rs139130053, OR = 0.52, p = 4.39 × 10–8). This evidence concerns the gene APOE and Alzheimer disease.