In addition to the APOE region, genome-wide significant associations were observed in an intergenic region near the EPHA5 gene (rs141838133, p = 2.19 × 10–8) in individuals with onset < 75 years, in GRIN3B near the known AD risk gene ABCA7 (rs115882880, p = 3.83 × 10–8) in females, and near TSPEAR (rs139130053, p = 4.27 × 10–8) in APOE-ε4 non-carriers. The gene discussed is EPHA5; the disease is Alzheimer disease.