Furthermore, when 4T1 cells overexpressing hTROP2 were implanted into the mammary fat pads of mice and treated with αTROP2-DPP4 and an equivalent amount of control antibody, αTROP2-DPP4 significantly inhibited tumor proliferation (Fig. 7K) and extended the survival of the mice (Fig. 7L), while also mediating a significant degradation of intratumoral sICOSL (Fig. 7M). The gene discussed is DPP4; the disease is neoplasm.