Interestingly, when we interfered with Mfsd4a in melanocytes and treated them with exogenous inflammatory cytokines, only administrating with exogenous IL-6 reversed the inhibitory effect of Mfsd4a interference on the JAK/STAT3 signaling pathway, indicating that filiform fire needle treats vitiligo by inhibiting Mfsd4a expression through inhibiting IL6, thereby decreasing JAK/STAT3 signaling pathway activity and regulating melanocyte viability. This evidence concerns the gene IL6 and vitiligo.