By cancer type, breast cancer and colorectal cancer demonstrated significant DFS associations, whereas RFS results were mixed for breast cancer due to conflicting HMG-CoA effects (HR = 0.83, 95% CI: 0.31–2.19, I2 = 62.8%) and strong harmful associations for colorectal cancer, with single-study estimates for SOAT1, HMG-CoA, hepatocellular carcinoma, lung cancer, and adrenocortical carcinoma limiting comprehensive subgroup analyses. The gene discussed is SOAT1; the disease is colorectal cancer.