In a separate study of 72 patients with T1DM and overweight or obesity, liraglutide (1.2 mg and 1.8 mg) over 12 weeks resulted in modest reductions in glucose levels, HbA1c, and significant weight loss (5 ± 1 kg), along with small reductions in total insulin dose (-10-12 IU). This evidence concerns the gene INS and type 1 diabetes mellitus.