GLP1R and obesity due to melanocortin 4 receptor deficiency: This review aims to fill that knowledge gap and explore the interplay between obesity and T1DM, available data on the role of the gut-brain axis, as well as discuss the most prevalent current interventions for weight management in patients with a BMI ≥ 27 kg/m2, including GLP-1 receptor agonist (GLP-1RA) therapy and bariatric surgery (BS).