By integrating our ChIP-seq and RNA-seq data with transcriptome of normal and CRC tissues in TCGA database, we identified five differentially expressed genes (GRAMD1A, PTK7, SPARC, SPHK1 and TMEM241) potentially regulated by H3K9la (Fig. 4D, Fig. S5D). This evidence concerns the gene SPHK1 and colorectal carcinoma.