By integrating our ChIP-seq and RNA-seq data with transcriptome of normal and CRC tissues in TCGA database, we identified five differentially expressed genes (GRAMD1A, PTK7, SPARC, SPHK1 and TMEM241) potentially regulated by H3K9la (Fig. 4D, Fig. S5D). The gene discussed is SPARC; the disease is colorectal carcinoma.