RUNX3 and acute myeloid leukemia: To study the interplay between intracellular redox state and Mcl-1 upregulation upon the acquisition of VEN resistance, we generated the VEN-R AML cells (VEN-R MOLM14 and VEN-R OCI-AML2) from VEN-sensitive or parental (VEN-S) MOLM14 and OCI-AML2 cells (Figs. 1A, S1A, Supplementary Method).