The effects of this treatment combination were also recapitulated in other VEN-R cell lines of OCI-AML2, OCI-Ly1, and Su-DHL4 (Figs. 7B, G and S12A, B) and primary CLL patient samples (Figs. 7H, I and S13A). Here, RUNX3 is linked to B-cell chronic lymphocytic leukemia.