Furthermore, although it remains unclear whether MATR3 and hnRNPA1 regulate REST mRNA through a mechanism similar to that of FUS, most ALS-associated mutations in these three RBPs are located within their IDRs (Beijer et al, 2021; Kapeli et al, 2017; Malik and Barmada, 2021). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.