TARDBP and amyotrophic lateral sclerosis: Furthermore, restoration of UNC13A expression in TDP-43–depleted neurons derived from induced pluripotent stem cells (iPSCs) was found to fully rescue impaired presynaptic function (Keuss et al, 2024), suggesting that the downregulation of UNC13A that results from TDP-43 loss underlies the disruption of synaptic integrity apparent in ALS.