Further analysis of the cluster of commonly downregulated genes embedded within these neuronal pathways identified UNC13A—a gene implicated in the synaptic vesicle cycle—as the only gene overlapping with the 48 genes categorized in ALS online database (ALSoD) as having statistical support, clinical relevance, or strong to moderate genetic evidence for ALS pathogenesis (van Es et al, 2009; Wroe et al, 2008) (Fig. 1C; Dataset EV1; Appendix Table S1). Here, UNC13A is linked to amyotrophic lateral sclerosis.