Among the genes mutated in ALS, however, several—including those for TDP-43 (TAR DNA-binding protein–43), MATR3 (matrin 3), FUS (fused in sarcoma), and hnRNPA1 (heterogeneous nuclear ribonucleoprotein A1)—encode RNA-binding proteins (RBPs) that share an important role in RNA metabolism (Johnson et al, 2014; Kim et al, 2013; Van Deerlin et al, 2008; Vance et al, 2009; Xue et al, 2020). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.