HTT and juvenile Huntington disease: Conversely, in Huntington’s disease, the mutated huntingtin protein induces abnormal REST accumulation in the nucleus and consequent suppression of the expression of genes such as that for brain-derived neurotrophic factor (BDNF) that are required for neuronal survival, thereby contributing to neurodegeneration (Soldati et al, 2013; Zuccato et al, 2007; Zuccato et al, 2003).