REST and amyotrophic lateral sclerosis: Furthermore, neurite regrowth following axotomy was found to be impaired in motor neurons derived from iPSCs harboring an ALS-associated FUS mutation (Stoklund Dittlau et al, 2021), suggesting the possibility that FUS dysfunction might lead to the overexpression or activation of REST, which in turn might be responsible for the inhibition of neuronal regeneration.