These key genes exhibit a state of overexpression, facilitating the upregulation of the NF-κB pathway as well as the growth and survival of MM.390,393 In this context, Catuogno et al.393 selected a BCMA-targeted internalizing RNA aptamer (apt69.T) via Cell-SELEX, which demonstrated the inhibitory capacity on the APRIL-induced NF-κB pathway. This evidence concerns the gene TNFSF13 and Miyoshi myopathy.