The construction of AA and atherosclerosis models and measurement of relevant indicators revealed that, compared to Col1a2+/G610C:ApoE−/−, both hSOSTki:Col1a2+/G610C:ApoE−/− and Δloop3-hSOSTki:Col1a2+/G610C: ApoE−/− exhibited significantly reduced AA incidence, smaller maximum diameters of the aortic arch and renal artery, lower proportions of atherosclerotic lesions at the aortic root, and decreased serum levels of IL-6, TNFα and monocyte chemoattractant protein-1 (MCP-1) (Fig. S6). The gene discussed is CCL2; the disease is atherosclerosis.