Therefore, targeting the AXII/AXIIR axis represents a promising strategy for developing treatments against the MM niche.388 Zhou et al.389 have identified an ssDNA aptamer (wh6) that can specifically bind to MM cells expressing AXII both in vitro and vivo, and it can also suppress the adhesion and progression of MM cell lines induced by AXII. This evidence concerns the gene ANXA2R and Miyoshi myopathy.