If p53 mutations occur simultaneously (KGPCER mice, Ptf1aCreER; KRASG12D; Tp53 LoxP/+; Rosa26-LSL-rtTA; TetO-GnasR201C), it can further develop into PDAC on the basis of IPMN [59]. The gene discussed is TP53; the disease is pancreatic intraductal papillary-mucinous neoplasm.