ZMPSTE24 and Hutchinson-Gilford progeria syndrome: In mice, ZMPSTE24 deficiency causes many of the same phenotypes that have been documented in gene-targeted models of HGPS (e.g., alopecia, failure-to-thrive, bone fractures, loss of adipose tissue, and progressive weight loss); those phenotypes are severe and invariably result in premature death [36, 37].