ATG7 and cancer: After subcutaneously injecting 4T1 (BALB/C mouse) or MDA-MB-231 (BALB/C-NU mouse) cells mixed with wild-type (WT) or Atg7−/− MEFs into mammary fat pad, the cancer cells mixed with Atg7−/− MEFs both generated tumors of greater volume and weight than that mixed with WT MEFs or injected alone, respectively (Fig. 1F, G, Supplementary Fig. 1E–G).