DHODH and type 1 diabetes mellitus: To confirm a functional in vivo relevance for T1D, we investigated DHODH inhibition in three mouse models characterized by different degrees of immune activation: 1) a model characterized by mild immune activation and presence of early stages of islet autoimmunity (NOD mouse model), 2) one model defined by an aggressive phenotype (transfer model of accelerated T1D) on the NOD background and 3) one model with a fast and aggressive onset of T1D (RIP-LCMV-GP mouse model).