In addition, NRF2 is an important player in antioxidant defense against cardiovascular pathologies [125] that are also present in HGPS patients [30], and previous studies highlighted the cardioprotective role of NRF2 by inhibiting NF-kB-mediated inflammatory responses, which are present in HGPS patients. The gene discussed is NFKB1; the disease is Hutchinson-Gilford progeria syndrome.