Furthermore, an integrated node network analysis revealed 3 distinct GLP-1 RA adverse events–mentioned clusters: cluster 1 (purple) contained allergies, anxiety, depression, chronic obstructive pulmonary disease, fatigue, fever, hypertension, indigestion, insomnia, gastroesophageal reflux disease, hives, swelling, restlessness, and seizures. This evidence concerns the gene GCG and gastroesophageal reflux disease.