Furthermore, an integrated node network analysis revealed 3 distinct GLP-1 RA adverse events–mentioned clusters: cluster 1 (purple) contained allergies, anxiety, depression, chronic obstructive pulmonary disease, fatigue, fever, hypertension, indigestion, insomnia, gastroesophageal reflux disease, hives, swelling, restlessness, and seizures. The gene discussed is GCG; the disease is major depressive disorder.