These findings build upon an earlier mixed methods study that analyzed Reddit, YouTube, and TikTok to assess the impact of GLP-1 RAs on mental health [7], finding 3 overarching mental health–related themes: insomnia (n=620 matches), anxiety (n=353), and depression (n=204); these mental health conditions were also detected in our analysis. Here, GLP1R is linked to major depressive disorder.