Prior studies using L‐lactate concentrations (e.g., 40 mM) showed enhanced tumor infiltration, granzyme B and interferon‐γ in activated CD8+ T‐cells (Barbieri et al., 2023), demonstrating that lactate is a critical regulator of T‐cell function and signaling pathways in response to physiological stressors such as exercise (Barbieri et al., 2023; Cai et al., 2023). The gene discussed is GZMB; the disease is neoplasm.