APLNR and myocardial infarction: When examining the genes that are differentially expressed in the cmAKO × myocardial infarction interaction term (the unique response of cmAKO to LCA ligation), we observe a large number of genes that are enriched in specific cell types, such as Timp4 (fibroblasts) [20], Zbtb16 (cardiomyocytes) [21], and Aplnr (cardiomyocytes) [22] (Fig 1D and S1 Table).