IL6 and acne: In individuals carrying the AG or GG genotypes, particularly under circadian disruption such as night shifts or artificial light exposure, these molecular disturbances may promote excessive sebum production, increased inflammatory cytokine expression (e.g.,: IL-1β, IL-17, IL-6, TNF-α, IFN-γ) [63], and skin barrier dysfunction, ultimately contributing to acne susceptibility [63,64].