TRPM8 and melanoma: TRPM8,a transient receptor potential cation channel, plays a crucialrole in calcium homeostasis and cellular signaling, processes oftendysregulated in cancer and, particularly, in melanoma.−,  TRPM8 was identified by both IVS (Tables ,  and Figure A–D) and transcriptomicdata (Table ) as atop target for compound 31, exhibiting elevated mRNAexpression in melanoma cells with respect to HaCaT cells.