The results revealed that the SERPINH1-PLOD1-ITGA5-ESM1 gene set was significantly associated with overall survival of patients with CESC, KIRP (kidney renal papillary cell carcinoma), LGG (brain lower grade glioma), and MESO (mesothelioma) (Fig 6J). This evidence concerns the gene ITGA5 and cervical squamous cell carcinoma.